LC-MS in Drug Bioanalysis

16.07.2012

Englisch

9781461438274

Springer US

Nein

472

1

Gebundene Ausgabe

Bioanalysis, LC-MS, LC-MS/MS, Liquid chromatography, MS, anticancer drugs, antidementia drugs, antidepressants, antiepileptic drugs, antifundal drugs, antimicrobial drugs, antipsychotic drugs, antiretroviral Drugs, anxiolytic/hypnotic drugs, cardiac drugs, drugs for addiction, immunosuppressants, mass spectrometry, metabolites, mood stabilizers

PNFS - Spektroskopie, Spektrochemie, Massenspektrometrie PNF - Analytische Chemie MKG - Pharmakologie

Internal standards for quantitative LC-MS bioanalysis.- Method development, validation and sample analysis for regulated quantitative bioanalysis using LC-MS/MS.- Impact of sampling paper/cards on bioanalytical quantitation via dried blood spots by liquid chromatography - mass spectrometry.- Highly sensitive pharmaceutical and clinical analysis using selective solid-phase extraction coupled to microflow liquid chromatography and isotope-dilution mass spectrometry.- Pitfalls of LC-MS/MS in the clinical laboratory.- Therapeutic drug monitoring to support clinical pharmacogenomics.- Liquid chromatography - mass spectrometry for the determination of antidepressants and some of their major metabolites in human biological matrices.- The analysis of antipsychotic drugs in human biosamples by LC-MS.- Therapeutic drug monitoring of targeted anticancer therapy - tyrosine kinase inhibitors and selective oestrogen receptor modulators: a clinical pharmacology laboratory perspective.- Applications of mass spectrometry in analyses of steroid hormones.- Liquid chromatography - mass spectrometric analysis of tropane alkaloids in mammalian samples: techniques and applications.- Analysis of illicit drugs in human biological samples by LC-MSn.- Use of matrix assisted laser desorption/ionization imaging mass spectrometry (MALDI-IMS) in the development of novel small molecule drugs.- A planar integrated micro mass spectrometer.

235 mm

15.5 cm