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Bücher Englische Bücher Wissen & Bildung Naturwissenschaft, Medizin, Informatik, Technik Medizin Nichtklinische Fächer Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy
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Platinum and Other Heavy Metal Compounds in Cancer Chemotherapy
(Gebundene Ausgabe, Englisch)
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Beschreibung
Cisplatin, the first member of the family of platinum-containing chemotherapeutic agents, was discovered by Barnett Rosenberg in 1965 and approved by the FDA for marketing in 1978. After 30 years of use in the clinic, cisplatin remains a central element of many treatment regimens. Cisplatin is still an irreplaceable component of a regimen that produces high cure rates in even advanced… nonseminomatous germ-cell cancers, and is widely used in the treatment of ovarian cancers and other gynecologic cancers, head and neck, and numerous other tumor types. The development of carboplatin has reduced some of the adverse events associated with cisplatin treatment, and the introduction of the DACH platinum compound oxaliplatin has broadened the spectrum of activity of the platinums to include gastro-intestinal cancers, especially colorectal cancer. The clinical importance of this family of drugs continues to drive investigation into how these drugs work and how to improve their efficacy and reduce their toxicity. The papers in this volume were presented in Verona, Italy, during the tenth International Symposium on Platinum Coordination Compounds in Cancer Chemotherapy. The symposium was jointly organized by the Department of Oncology of the Mater Salutis Hospital – Azienda Sanitaria Locale 21 of the Veneto Region – and by the Department of Medicine and Public Health, Section of Pharmacology, the University of Verona. They reflect the vitality of this field and the increasing use of new molecular and cell biologic, genetic, and biochemical tools to identify approaches to further improve their use. Dieses Produkt haben wir gerade leider nicht auf Lager.
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Technische Daten
Erscheinungsdatum
18.12.2008
Sprache
Englisch
EAN
9781603274586
Herausgeber
Humana Press
Serien- oder Bandtitel
Cancer Drug Discovery and Development
Sonderedition
Nein
Seitenanzahl
398
Einbandart
Gebundene Ausgabe
Buch Untertitel
Molecular Mechanisms and Clinical Applications
Schlagwörter
Antiproliferative, Cancer Chemotherapy, Carcinom, Cellular Transport, DACH-platinum, DNA repair, Heavy Metal Compounds, Pharmacophore, Platinum, neurotoxicity, positron emission tomography
Thema-Inhalt
MJCL - Onkologie
MKG - Pharmakologie
Höhe
235 mm
Breite
15.5 cm
Hersteller: Springer Nature Customer Service Center GmbH, Europaplatz 3, Heidelberg, Deutschland, 69115, ProductSafety@springernature.com
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